Decatungstate‐Mediated C(sp <sup>3</sup> )–H Heteroarylation via Radical‐Polar Crossover in Batch and Flow
نویسندگان
چکیده
Photocatalytic hydrogen atom transfer is a very powerful strategy for the regioselective C(sp3)–H functionalization of organic molecules. Herein, we report on unprecedented combination decatungstate photocatalysis with oxidative radical–polar crossover concept to access direct net-oxidative heteroarylation. The present methodology demonstrates high functional group tolerance (40 examples) and scalable when using continuous-flow reactor technology. developed protocol also amenable late-stage biologically relevant molecules such as stanozolol, (−)-ambroxide, podophyllotoxin, dideoxyribose.
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2021
ISSN: ['1521-3773', '1433-7851', '0570-0833']
DOI: https://doi.org/10.1002/ange.202104682